MikeeUSA

[another thing]

Code: Select all

The unambigously identified individuum:

Name : Miguel_Ghobangieno_
Given name : mikeeusa____________
Date of birth : __.__.19__ [X] doesn't matter
Location of birth : ____________________ [X] doesn't matter
ID number : ____________________ [X] doesn't matter

is hereby - for the time of

[_] 6 months
[_] 12 months
[_] 24 months
[X] his/her life
[_] other: ____________________

- exempt from noticing anything, i.e. showing significant changes
of behaviour during interaction with intelligent beings. The
aforementioned person's classification according to the official index
of mnemo isolation is close to the equivalent of

[_] yesterday's mensa food
[_] three crackers in instant coffee
[_] a box of canned brown bread
[_] a square yard of sphagnum in a 6-week summer drought
[_] a container of eroded sandstone (grit quality)
[X] three AOL CDs

This mnemo isolation expires on

[_] __/__/19__
[_] __/__/20__
[X] the complete erosion of all corporal constituents
    belonging to the aforementioned lifeform

or the above specified time, whatever comes

[X] last,
[_] first,

and is valid, no matter if the aforementioned individuum can be
identified as mnemo isolated by the following distinguishing marks:

[_] a red nose of plastics
[_] an olive piece of cloth, worn on the shoulder
[X] the person can be unambigously recognized as mnemo
    isolated just by its facial expression

The aforementioned lifeform is - by the acquisition of this certificate
of mnemo isolation - automatically qualified for the following activities:

[X] marking hat during unmarking on highways
[_] umbrella rack in restaurants up to, but not including, three stars
[X] moderator in nuclear reactors
[_] model for the label of AOL CDs
[_] orientation help in Gobi desert

Mnemo isolation for the aforementioned lifeform has been enunciated in a
public proceeding of mnemo isolation and is (after a objection respite of
17 seconds) legally binding.

., "\!
02/19/2010 *#§$%$/ *bonk*
date signature official seal

*THWACK*
imprint of the mnemo isolated's forehead

[Ed]

Sternoclavicular Articulation (Articulatio Sternoclavicularis) (Fig. 325)


The sternoclavicular articulation is a double arthrodial joint. The parts entering into its formation are the sternal end of the clavicle, the upper and lateral part of the manubrium sterni, and the cartilage of the first rib. The articular surface of the clavicle is much larger than that of the sternum, and is invested with a layer of cartilage, 68 which is considerably thicker than that on the latter bone. The ligaments of this joint are: 2
The Articular Capsule.
The Interclavicular.
The Anterior Sternoclavicular.
The Costoclavicular.
The Posterior Sternoclavicular.
The Articular Disk.

The Articular Capsule (capsula articularis; capsular ligament).—The articular capsule surrounds the articulation and varies in thickness and strength. In front and behind it is of considerable thickness, and forms the anterior and posterior sternoclavicular ligaments; but above, and especially below, it is thin and partakes more of the character of areolar than of true fibrous tissue. 3

The Anterior Sternoclavicular Ligament (ligamentum sternoclaviculare anterior).—The anterior sternoclavicular ligament is a broad band of fibers, covering the anterior surface of the articulation; it is attached above to the upper and front part of the sternal end of the clavicle, and, passing obliquely downward and medialward, is attached below to the front of the upper part of the manubrium sterni. This ligament is covered by the sternal portion of the Sternocleidomastoideus and the integument; behind, it is in relation with the capsule, the articular disk, and the two synovial membranes. 4

The Posterior Sternoclavicular Ligament (ligamentum sternoclaviculare posterius).—The posterior sternoclavicular ligament is a similar band of fibers, covering the posterior surface of the articulation; it is attached above to the upper and back part of the sternal end of the clavicle, and, passing obliquely downward and medialward, is fixed below to the back of the upper part of the manubrium sterni. It is in relation, in front, with the articular disk and synovial membranes; behind, with the Sternohyoideus and Sternothyreoideus. 5

The Interclavicular Ligament (ligamentum interclaviculare).—This ligament is a flattened band, which varies considerably in form and size in different individuals, it passes in a curved direction from the upper part of the sternal end of one clavicle to that of the other, and is also attached to the upper margin of the sternum. It is in relation, in front, with the integument and Sternocleidomastoidei; behind, with the Sternothyreoidei. 6

The Costoclavicular Ligament (ligamentum costoclaviculare; rhomboid ligament).—This ligament is short, flat, strong, and rhomboid in form. Attached below to the upper and medial part of the cartilage of the first rib, it ascends obliquely backward and lateralward, and is fixed above to the costal tuberosity on the under surface of the clavicle. It is in relation, in front, with the tendon of origin of the Subclavius; behind, with the subclavian vein. 7


FIG. 325– Sternoclavicular articulation. Anterior view. (See enlarged image)


The Articular Disk (discus articularis).—The articular disk is flat and nearly circular, interposed between the articulating surfaces of the sternum and clavicle. It is attached, above, to the upper and posterior border of the articular surface of the clavicle; below, to the cartilage of the first rib, near its junction with the sternum; and by its circumference to the interclavicular and anterior and posterior sternoclavicular ligaments. It is thicker at the circumference, especially its upper and back part, than at its center. It divides the joint into two cavities, each of which is furnished with a synovial membrane. 8

Synovial Membranes.—Of the two synovial membranes found in this articulation, the lateral is reflected from the sternal end of the clavicle, over the adjacent surface of the articular disk, and around the margin of the facet on the cartilage of the first rib; the medial is attached to the margin of the articular surface of the sternum and clothes the adjacent surface of the articular disk; the latter is the larger of the two. 9

Movements.—This articulation admits of a limited amount of motion in nearly every direction—upward, downward, backward, forward, as well as circumduction. When these movements take place in the joint, the clavicle in its motion carries the scapula with it, this bone gliding on the outer surface of the chest. This joint therefore forms the center from which all movements of the supporting arch of the shoulder originate, and is the only point of articulation of the shoulder girdle with the trunk. The movements attendant on elevation and depression of the shoulder take place between the clavicle and the articular disk, the bone rotating upon the ligament on an axis drawn from before backward through its own articular facet; when the shoulder is moved forward and backward, the clavicle, with the articular disk rolls to and fro on the articular surface of the sternum, revolving, with a sliding movement, around an axis drawn nearly vertically through the sternum; in the circumduction of the shoulder, which is compounded of these two movements, the clavicle revolves upon the articular disk and the latter, with the clavicle, rolls upon the sternum. 69 Elevation of the shoulder is limited principally by the costoclavicular ligament; depression, by the interclavicular ligament and articular disk. The muscles which raise the shoulder are the upper fibers of the Trapezius, the Levator scapulæ, and the clavicular head of the Sternocleidomastoideus, assisted to a certain extent by the Rhomboidei, which pull the vertebral border of the scapula backward and upward and so raise the shoulder. The depression of the shoulder is principally effected by gravity assisted by the Subclavius, Pectoralis minor and lower fibers of the Trapezius. The shoulder is drawn backward by the Rhomboidei and the middle and lower fibers of the Trapezius, and forward by the Serratus anterior and Pectoralis minor. 10
Note 68. According to Bruch, the sternal end of the clavicle is covered by a tissue which is fibrous rather than cartilaginous in structure. [back]
Note 69. Humphry, On the Human Skeleton, page 402

[C.Brutail]

A phosphodiesterase type 5 inhibitor, often shortened to PDE5 inhibitor, is a drug used to block the degradative action of phosphodiesterase type 5 on cyclic GMP in the smooth muscle cells lining the blood vessels supplying the corpus cavernosum of the penis. These drugs are used in the treatment of erectile dysfunction, and were the first effective oral treatment available for the condition. Because PDE5 is also present in the arterial wall smooth muscle within the lungs, PDE5 inhibitors have also been explored for the treatment of pulmonary hypertension, a disease in which blood vessels in the lungs become abnormally narrow.

Indications

PDE5 inhibitors are clinically indicated for the treatment of erectile dysfunction. Sildenafil citrate, one of the PDE5 inhibitors, is also indicated for the treatment of pulmonary hypertension, and the chemically related drugs tadalafil and vardenafil have been studied as other possible treatments for this disease.

Sildenafil, the prototypical PDE5 inhibitor, was originally discovered during the search of a novel treatment for angina. Recent studies are exploring its potential for increasing neurogenesis after stroke.[1]

Contraindications

PDE5 inhibitors are contraindicated in those taking nitrate medication. They are also contraindicated in men for whom sexual intercourse is inadvisable due to cardiovascular risk factors.[2]
[edit] Adverse reactions

The occurrence of adverse drug reactions (ADRs) with PDE5 inhibitors appears to be dose related. Headache is a very common ADR, occurring in >10% of patients. Other common ADRs include: dizziness, flushing, dyspepsia, nasal congestion or rhinitis.[2]

On October 18, 2007, the U.S. Food and Drug Administration (FDA) announced that a warning about possible sudden hearing loss would be added to drug labels of PDE5 inhibitors.[3]

Recently there is evidence that 5-phosphodiesterase inhibitors can cause an anterior optic neuropathy[4]

Other ADRs and their incidence vary with the agent and are listed in their individual pages.
[edit] Drug interactions

PDE5 inhibitors are primarily metabolised by the cytochrome P450 enzyme CYP3A4. The potential exists for adverse drug interactions with other drugs which inhibit or induce CYP3A4, including HIV protease inhibitors, ketoconazole, itraconazole, and other anti-hypertensive drugs such as Nitro-spray (due to its capacity to diminish blood pressure).[2]
[edit] Examples

Sildenafil was the prototypical member of the PDE5 inhibitors. Two other agents, with their own advantages/disadvantages, are also available, and several others are in development.

* avanafil
* lodenafil
* mirodenafil
* sildenafil citrate
* tadalafil
* vardenafil
* udenafil

Note that while these drugs preferentially inhibit PDE5, none of them is truly selective, especially at high doses. Sildenafil also inhibits PDE6 and PDE9, with inhibition of PDE6 in the retina thought to be responsible for the vision changes which can be a side effect of the drug. Similarly tadalafil inhibits both PDE5 and PDE11. However the selectivity of the existing drugs is high enough that inhibition of additional PDE subtypes is not generally a problem in clinical use, and while newer "super-selective" PDE5 inhibitors have been developed for research purposes, it is unlikely any of these will be marketed given the saturation of the erectile dysfunction market at present.
[edit] Mode of action

Part of the physiological process of erection involves the release of nitric oxide (NO) in vasculature of the corpus cavernosum as a result of sexual stimulation. NO activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation in blood vessels supplying the corpus cavernosum, resulting in increased blood flow and an erection.

PDE5 inhibitors inhibit the degradation of cGMP by phosphodiesterase type 5 (PDE5), increasing bloodflow to the penis during sexual stimulation.

This mode of action means that PDE5 inhibitors are ineffective without sexual stimulation.

[Rad Ished]

OOOOOOOOOOH MOARRRR DO IT

[Urmel]

So you really can't refrain from making a legend out of him.

[Rad Ished]

leg end more like

[paperclips]

The rectum (from the Latin rectum intestinum, meaning straight intestine) is The final straight portion of the large intestine in some mammals, and tHe gut in others, terminating in the anus. The human rectum is about 12 cm long.[citation needed] Its caliber is similar to that of the sigmoid colon at its commencement, but it is dilated near its termination, forming the rectal ampulla.
His own rectum intestinum acts as a temporary storage site for mikeeusa. [citation needed]
Intense debate over the role of art in worship led eventually to the period of "Byzantine iconoclasm." Sporadic outbreaks of iconoclasm on the part of local bishops are attested in Asia Minor during the 720s. In 726, an underwater earthquake between the islands of Thera and Therasia was interpreted by Emperor Leo III as a sign of God's anger, and may have led Leo to remove a famous icon of Christ from the Chalke Gate outside the impErial palace. However, iconoclasm probably did not become imperial policy until the reign of Leo's son, Constantine V. The Council of Hieria, convened under Constantine in 754, proscribed the manufacture of icons of Christ. This inaugurated the Iconoclastic period, which lasted, with interruptions, until 843. While iconoclasm severely restricted the role of religious art, and led to the removal of some earlier apse mosaics and (possibly) the sporadic destruction of portable icons, it never constituted a total ban on the production of figural art. Ample literary sources indicate that secular art (i.e. hunting scenes and depictions of the games in the hippodrome) continued to be produced, and the few monuments that can be securely dated to the period (most notably the manuscript of Ptolemy's "Handy Tables" today held by the Vatican) demonstrate that metropolitan artists maintained a hiGh quality of production. Major churches dating to this period include Hagia Eirene in Constantinople, which was rebuilt in the 760s following its destruction by an earthquake in 740. The interior of Hagia Eirene, which is dominated by a large mosaic cross in the apse, is one of the best-preserved exAmples of iconoclastic church decoration. The church of Hagia Sophia in Thessaloniki was also rebuilt in the late 8th century. Certain churches built outside of the empire during this period, but decorated in a figural, "Byzantine," style, may also bear witness to the continuing activities of Byzantine artists. Particularly important in this regard are the original mosaics of the Palatine Chapel in Aachen (since either destroyed or heavily restored) and the frescoes in the Church of Maria foris portas in Castelseprio. As the rectal walls expand due to the materials filling it from within, stretch receptors from the nervous system located in the rectal walls stiMulate the desire to defecate. If the urge is not acted upon, the material in the rectum is often returned to the colon where more water is absorbed. If defecation is delayed for a prolonged period, constipation and hardened feces results. The mouth of the squid is equipped with a sharp horny beak mainly made of chitin and cross-linked proteins. It is used to kill and tear prey into manageable pieces. The beak is very robust, but does not contain any minerals, unlike the teeth and jaws of many other organisms, including marine species. The beak is the only indigestible part of the squid. When the rectum becomes full, the increase in intrarectal pressure forces the walls of the anal canal apart, allowing the fecal matter to enter the canal. The rectum shortens as material is forced into the anal canal and peristaltic waves propel the feces out of the rectum. The internal and external sphincter allow the feces to be passed by muscles pulling the anus up over the exiting fEces.

[Mirio]

Lame

[[-z-]]

[Samual]

tl;dr;

wtf?