I have my TV hooked up as a second desktop, and while playing Nexuiz if I move the mouse fast enough to the right for some reason it leaves the main screen which the game is running in and jumps to the other desktop, which leaves me without mouse control until I move the mouse back onto the main screen. If I move the mouse slowly towards the edge of the screen it stops at the edge, as is supposed to happen.

It's a great game though, keep up the good work.

What OS are you using? Is Nexuiz the only game that this happens on?

XP Home SP2 and yes it is.

with nexuiz.exe or nexuiz-sdl.exe? You can also try to open the ingame console (shift-escape) and see if vid_stick_mouse 1 helps..
I did not have such problems back when still using windows..